CLUSTAL O(1.1.0) multiple sequence alignment


Human           -MAAASSSDSDACGAESNEANSKWLDAH---YDPMANIHTFSACLALADLHGDGEYKLVV
Chimp           -MAAASSSDSDACGAESNEANSKWLDAH---YDPMANIHTFSACLALADLHGDGEYKLVV
Dog             -MAAASSSDSDSGRAESSEASSKWLDAH---YDPMANIHTFSSCLALADLHGDGEYKLVV
Cow             -MAATSSSDSDGGKGESSEANSKWLDSL---SDSMANIHTFSACLALADFHGDGEYKLAM
Mouse           -MAAASSSDSDSGRAESNEANSKWLDAH---YDPMANIHTFSSCLSLADLHGDGEYKLVV
Rat             MAATTSSPDSDSGRAESNEANSKWLDAH---YDPMANIHTFSSCLALADLHGDGEYKLVV
Zebra_fish      ------MSSVPQELKDTSVASSKWLDAH---YDPVANLYTFSSCIALSDLHGDGENKLVV
Fruit_Fly       -----------------MAGAPNWLHVDTAEEAPPPHLTTLTSCMALSDVQCDGYVRLLA
C._elegans      ------------MAKPVNVNQSKWTVPV---LLKECEIYCPSTCVAFGPILSDNDSKLII
                                      :*            .:   ::*:::. .  *   :*  

Human           GDLGPG----GQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCV
Chimp           GDLGPG----GQQPCLKVLKGPLVMNESPLPALPAAAATFLMEQHEPRTPALALASGPCV
Dog             GDLGPS----GQHPRLKVLKGPTVLTESPLPALPAAAATFLMEQHEPRTPALALASGPCV
Cow             GDLGPD----GRQPRLKVLKGHTLVSQKPLPDLPAAAVTFLMASHEPRTPALAIASGPCV
Mouse           GDLGPG----GQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCV
Rat             GDLGPG----GQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCV
Zebra_fish      GDLGTG----LCNMKLKVYRGTGLLSESTLLDLPTGLVSFLMDLHEPRTPAIAVASGPFI
Fruit_Fly       ADISLDNAAEEPTATLKVFRGLKLKHEQPLPGIPAAIESLYIDETEPKTPVIAVAIAESV
C._elegans      AHGGHR----GVNMKLKVFQQLEQLSESSLADMPTALVHFINDLS--SIPSIAVAAGPSL
                .. .           *** :      :. *  :*:.   :         * :*:* .  :

Human           YVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPL-SIQS
Chimp           YVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPL-SIQS
Dog             YVYKNLKPYFKFTLPQLPPNPLEQDLWNQVKEDRIDPLTLKEMLEGIREKAEVPL-SVQS
Cow             YVYKNLKPYFKFSLPSLPTNPLEQDLWNQAKEDQIDPLTLKEMLEGIREKAEVPL-SVQS
Mouse           YVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEDQIDPLTLKEMLEDIREKADVPL-SVQS
Rat             YVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLEDIREKAEVPL-SVQS
Zebra_fish      YVYKNMRPYFKFTLPSLDINPLEQDVWCQAKEDMIDPMTLKEMLEGLRDKSEIPL-SVRS
Fruit_Fly       LFYRHLKPYFKYTIPAQDSEDLELEVWRKLPVVK--PSAHPALLDSLK-TIDHSKLSRKS
C._elegans      LIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPIS
                 .*:.::*::*:::*    :  * : *           :   :*. :.        :  *

Human           LRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVL
Chimp           LRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVL
Dog             LRFLQLELSEMEAFVSQHKSKSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVL
Cow             LRFLPLELSEMEAFVNQHKSKSIRRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVL
Mouse           LRFLQLELSEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAASCLVLGTESKELLVL
Rat             LRFLQLELNEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVL
Zebra_fish      LRFLMLEPHEMENFVHLHKELPIRRQTVITCIGTLKKNMADEDAVSCLVIGTENGDVYIL
Fruit_Fly       QRLLQMGEQEREHFIATHKDSPVGRVGNIVAMCCIKRISSDANPPSHLVLATDTGHIMIL
C._elegans      QTYLRA-DKETQVVLVEHYGTKIANSATITCIAKLTKSTA--EPLDILVIGTEHCEIFLI
                   *     * : .:  *    : .   *. :  :.:  :  :  . **:.*:  .: ::

Human           DPEAFTILAKMS----LPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIE
Chimp           DPEAFTILAKMS----LPSVPPLLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIE
Dog             DPEAFTILAKMS----LPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKRPKYCIE
Cow             DPEAFTILAKMS----LPSVPAFLEASGQFDVEFRLAAACRNGSIYILRRDSKRPKYCIE
Mouse           DPEAFTILAKMS----LPSVPVFLEVSGQFDVEFRLTAACRNGSIYILRRDSKHPKYCIE
Rat             DPEAFTILTKMS----LPSVPVFLEVSGQFDVEFRLTAACRDGSIYILRRDSKHPKYCIE
Zebra_fish      DPEAFTILYKMS----LPSTPTLMDVTGQFDVEFRITVACRNGNIYILRRDSPKPKYCIE
Fruit_Fly       EPQGFNLVYQGKACDDETAVPSLISVQGTFETDFCIVVATRNGGVYLLRKSQSEGQEIFK
C._elegans      DSQAFTILETIK----IGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVI
                : :.*.::   .      :.*  : . * ::.:: : .  * . :: ::: .   :  . 

Human           LSAQPVGLIR--VHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQA
Chimp           LSAQPVGLIR--VHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQA
Dog             LSAQPVGLVR--VHKVLVVGSNQDTLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRSLQA
Cow             LGAQPVGLVG--VHKVLVVGSNQDSLHGFTYKGKRLWTVQMPAAILAMNLLEQHSRGLQA
Mouse           LSAQPVGLVR--VHKVLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQA
Rat             LSAQPVGLVR--VHKILVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQA
Zebra_fish      LSSHPVGLVR--MGKNVVVGCTHETLHGYTQKGKKLWTAYLPAPVTTMALMDLPTRGFQA
Fruit_Fly       LGIPLTGLLLLPIDQTIIASTMDNRYLCYSKRGKLLYQVPMSDLPVCLLPLPLTHLGLTL
C._elegans      SQSMITSMVL--VNKMIVYTTVENLIHFASFRGKKMNTVKCPSKIKMLEPFIYPLKQLAA
                     ..::   : : ::    .:     : :** :  .        :  :      :  

Human           VMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRT
Chimp           VMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRT
Dog             VMAGLANGEVHIYHDKALLNVIRTPDVVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRT
Cow             VMAALANEEVRIYHDKVLLNVIRTPEAVTSLCFGRYGREDNTLIMTTLGGGLIIKILKRT
Mouse           VMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRT
Rat             VMAALANGEVRIYRDKALLNVVRAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRT
Zebra_fish      VLVGLANCEVHMYRDKNLIGTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLIVKILKRT
Fruit_Fly       VAIALRGGVVKFYLQRYLVDEFVLEETVDAMLYGRMGMEDHVLTLVTQSGGIVVKILRRV
C._elegans      VI-AVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRK
                *  .:    :::* :: *:  .   . :  : :*  * ** .* :.   *.: ::*::* 

Human           AVFVEGGSEVGP--------PPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLY
Chimp           AVFVEGGSEVGP--------PPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLY
Dog             AVFVEARGEAGP--------PPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRTFQTDLY
Cow             AVFAEGGGEAGP--------PPSQAIKLNVPRKTRLYVDQTLREREAGTAMHRTFQADLY
Mouse           AVFVEGTGEVGP--------PLAQTTKLSVPRKTRLYVDQTLREREAGTAMHRTFQTDLY
Rat             AVFVEGTGEVGP--------PLAQTTKLSVPRKTRLYVDQTLREREAGTVMHRTFQTDLY
Zebra_fish      AVFDDRDSTPGP--------PIAQSIRLNVPKKTKLYVDQTLRERENAIAMHRAFQMDLS
Fruit_Fly       SRFEPKAGDLANKRALGDNKSIVDASILDKPKKSSIFVEQAAREKQQAKSTYGSFQVELW
C._elegans      ANFDTKLDYNQV--------PQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLF
                : *                    .:  *. *:*: :::: : ** : .   :  :* :* 

Human           LLRLRAARAYLQALESSLSPLSTT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLG
Chimp           LLRLRAARAYLQALESSLSPLSAT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLG
Dog             LLRLRAARAYVQALESSLNPVSVT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTARPILG
Cow             LLRLRAARAYVQALESSLSPVSLT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTARPILG
Mouse           LLRLRAARAYVQALESSLSPMSTT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLG
Rat             LLRLRAARAYVQALESSLSPMSAT-AREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLG
Zebra_fish      RLRLAAARAYVKALESSLTPMSAS-LTEPLKMNAVVQGLGPSFKLTLNIQNTAASRPVMN
Fruit_Fly       RLRHTAARATIDAINSSESTISGDLTHAPVKLSAEVCGSGPAFRLYLTVQNLSTFKMASN
C._elegans      DVKYRLAASYLELTSSASATVSTT-TVLPVEISVDIHGFGPTFRMTIHLLSSSK-QNLYD
                 ::   * : :.  .*:   :*      *::: . : * **:*:: : : . :  :    

Human           LLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESL-S--------NKGI-SDIIKV
Chimp           LLVCFLYNEALYSLPRPFFKVPLLVPGLNYPLETFVESL-S--------NKGI-SDIIKV
Dog             LLVCFLYNEVLYALPRAFFKVPLLVPGLNYPLETFVESL-S--------DKGI-SDIIKV
Cow             LVVCFLYNEVLYALPRAFFKVPLLVPGLNYPLETFVKSL-S--------DKGI-SDIIKV
Mouse           LHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESL-S--------SKGI-SDMIKV
Rat             LQVCFLYNEAFYALPRAFFKVPLLVPGLSYPLETFVESL-S--------SKGI-SDIIKV
Zebra_fish      LAISFLYDESLYSMRTAFFKIPLLVPGLNYPIDTFVECL-S--------DKGV-SDIIKV
Fruit_Fly       LVVLLHADRRHYTIPQTLARLPSVLPGVPLRVDFEVVAVLDPMDKLPPASLTPDNSLIRV
C._elegans      MHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCK-D--------PEKAANCDVRA
                : : :  :   * :   :  :  :  *    .   : .  .             .  ::.

Human           LVLREGQSAPLLSAHVNMPGSEGLAAA
Chimp           LVLREGQSAPLLSAHVNMPGSEGLAAA
Dog             LVLREGQSAPLLSAHINMPVSEGLEAT
Cow             LVLREGQSTPLLSAHINMPMSEGLAAD
Mouse           LVLREGQSAPLLSAHINMPVSEGLAAA
Rat             LVLREGQSAPLLSAHINMPVSEGLAAA
Zebra_fish      FVLREGKSAPLLTAHINMPVSEGLALN
Fruit_Fly       MLMKAGQAKPLIAAAISMPQSEAAF--
C._elegans      LLVHAKRATPIVTAVIKMPFSEFPLD-
                ::::  :: *:::* :.** **