This web page was produced as an assignment for Genetics 677 an undergraduate course at UW-Madison
The BBS1 Protein Interaction Network
What are Protein Interactions?
Protein interaction networks can be greatly useful when analyzing a protein and its function. This protein network above was obtained through STRING. STRING is a database of known and predicted protein interactions [1]. The interactions are both direct and indirect associations with BBS1. It shows all the proteins cited through various papers that interact with BBS1. It is important to see which proteins interact with BBS1 to fully understand how it functions in the human. By looking at which proteins interact with BBS1 one could learn new facts about the protein and how it functions.
Analysis and Discussion
The protein interaction map revealed a lot of information about the protein by seeing the different proteins that interact with it. Six of the proteins in the BBSome (BBS1, 2, 4, 5, 7, 9) were found in the protein network which was not surprising. BBS12 was also found in the protein network yet it is not apart of the BBSome. Upon further research, it was found that it did interact with the BBSome however it forms a different complex with BBS10 and 12 that interacts with the BBSome [2]. The RAB protein is interesting to find in the network. RAB proteins are known to function in transporting of other proteins similar to the BBSome [3]. Specifically, it is known to function as membrane organizers by trafficking membrane proteins themselves [3].
As one can see, the protein interaction network is smaller with most of the proteins interacting with BBS1 being those within the BBSome. This protein network indicates not much research has been done into the functional network of BBS1. By researching more proteins that may interact with BBS1 one could learn more about the functioning of the protein itself.
See future directions to see some possible proteins that may be important.
As one can see, the protein interaction network is smaller with most of the proteins interacting with BBS1 being those within the BBSome. This protein network indicates not much research has been done into the functional network of BBS1. By researching more proteins that may interact with BBS1 one could learn more about the functioning of the protein itself.
See future directions to see some possible proteins that may be important.
References:
[Banner Photo] "NDM-1" NDM-1. Retrieved 12 March 2013 from http://www.personal.psu.edu/czc5161/blogs/testing/references.html.
[1] STRING (Search Tool for the Retrieval of Interacting Genes/Proteins). N.p., n.d. Web. 23 Apr. 2013.
[2] Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC, Sheffield VC. (2010). BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Retrived from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824390/.
[3] Zerial M and McBride H. (2001). Rab proteins as membrane organizers. Nature Review, 2(2), 107-17. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11252952.
[Banner Photo] "NDM-1" NDM-1. Retrieved 12 March 2013 from http://www.personal.psu.edu/czc5161/blogs/testing/references.html.
[1] STRING (Search Tool for the Retrieval of Interacting Genes/Proteins). N.p., n.d. Web. 23 Apr. 2013.
[2] Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC, Sheffield VC. (2010). BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Retrived from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824390/.
[3] Zerial M and McBride H. (2001). Rab proteins as membrane organizers. Nature Review, 2(2), 107-17. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11252952.